High complement levels in astrocyte-derived exosomes of Alzheimer disease
نویسندگان
چکیده
منابع مشابه
Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.
OBJECTIVE Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. METHODS Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with AD (n = 20) both when cognitively normal and 1 to 10 years later when diagnos...
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Astrocytes use gliotransmitters to modulate neuronal function and plasticity. However, the role of small extracellular vesicles, called exosomes, in astrocyte-to-neuron signaling is mostly unknown. Exosomes originate in multivesicular bodies of parent cells and are secreted by fusion of the multivesicular body limiting membrane with the plasma membrane. Their molecular cargo, consisting of RNA ...
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1 Prior P, Symmons D P M, Hawkins C F, Scott D L, Brown R. Cancer morbidity in rheumatoid arthritis. Ann Rheum Dis 1984; 43: 128-31. 2 Symmons D P M, Ahern M, Bacon P A, et al. Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases. Ann Rheum Dis 1984; 43: 132-5. 3 Isaacson P, Wright D H. Coeliac discase and malignant histiocytosis of the intestine. In: Whitehouse J M A, Wi...
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that occurs due to spasms of the neurons, resulting in loss of memory and behavioral changes. In particular, synaptic loss has been described as an early event in the pathogenesis of AD. The increasing evidences have suggested the role of many matrix metalloproteinase (MMPs) in central nervous system (CNS) pathology. Many stud...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2018
ISSN: 0364-5134
DOI: 10.1002/ana.25172